Scientist II, Protein Biology

Work Schedule

Standard (Mon-Fri)

Environmental Conditions

Some degree of PPE (Personal Protective Equipment) required (safety glasses, gowning, gloves, lab coat, ear plugs etc.)

Job Description

Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science, with annual revenue of approximately $44 billion. Our Mission is to enable our customers to make the world healthier, cleaner, and safer. Whether our customers are accelerating life sciences research, solving analytical challenges, growing efficiency in their laboratories, improving patient health through diagnostics, or developing and manufacturing life-changing therapies, we are here to support them. Our distributed team delivers an outstanding combination of innovative technologies, purchasing convenience, and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, Patheon, and PPD. Our Innovative Laboratory technologies & Services makes it easier for customers.

About Team: Antibody team

The antibody team is involved in development and engineering of antibodies, with a deep focus on reagent quality and specificity. The core activities of team include design, development, purification, conjugation and testing of antibodies in a variety of immunoassay applications using state of the art tools and technologies. The goal of the program is advanced product development and creation of product specific information to promote research use.

Role:

To be an integral part of an antibody development team with a focus on performance and specificity using innovative molecular, protein, and cell biology methods.

Responsibilities:

·        Contribute in a fast- paced environment towards antibody screening & validation

·        Lead projects or workflows in new antibody development programs with vast experience in experimental planning and execution to meet the program objectives

·        Design and experimental execution, interpreting data and data presentations

·        Drive conceptualization within teams to enable development of successful protocols for effective transfer to functional teams

·        Serve as domain authority in protein biology to provide inputs and guidance towards driving innovation and cross team collaborations

·        Knowledge of product commercialization processes from concept to launch including early feasibility, development, and validation phases

·        Support manufacturing team for technical support and quality by providing technical guidance

Education & Experience levels:

Applicants should have Masters with over 5 years relevant experience or PhD with greater than 2 years’ experience in a life sciences field with a strong focus on protein biology, protein design, biophysical characterization, molecular biology, immunology, biotechnology or biochemistry.

Nature of experience:

·        Extensive experience with antibody development across single B cell, library display and other recombinant antibody platforms

·        Broad knowledge and experience in molecular biology, cell biology, immunoassays, protein design, engineering, purification, and conjugation fields to enable successful delivery on program goals

·        Expertise with antibody or protein design, biophysical characterization, and molecular biology using state of the art methodologies such as SPR and BLI

·        Expertise in antibody characterization methods including affinity measurements and epitope binning

·        Experience with protein expression, protein purification, and protein-protein interaction, protein structure -function relationships, and immunogen designs

·        Expertise in development of conjugation chemistries or performing antibody conjugations is desired

·        Proficient in molecular biology workflows such as high-throughput molecular cloning, plasmid vector construction, PCRs, Restriction digestion, Ligation, Transformation, Mini and maxi preps, sequencing

·        Thorough in biochemical and immunoassay workflows such as ELISA, SDS-PAGE, Western blotting, IF, IHC

·        Ability to provide technical trouble shooting to resolve scientific problems.

·        Proficient in software or platforms for molecular biology and sequence analysis, MS Office and statistical software such as GraphPad Prism.

·        Authorship of peer-reviewed publications and a strong, independent understanding of standard and emerging research protocols and techniques are preferred. GLP experience is a must.

The successful candidate will be self-motivated and a self-starter who is excellent at learning and applying new concepts for process or product improvements, possess excellent oral and written communication skills to connect to peers and leadership, and will be an excellent teammate with the ability to work with diverse colleagues.

Thermo Fisher Scientific is an equal opportunity employer and value diversity at our company. All qualified applicants will receive consideration for employment without discrimination basis race, color, religion, sex, sexual orientation, gender, gender identity or expression, national origin, protected veteran status, age, genetics, pregnancy, disability or any other legally protected status. Thermo Fisher Scientific aligns with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.

We offer competitive remuneration, annual incentive plan bonus, healthcare, and a range of employee benefits. Thermo Fisher Scientific offers employment with an innovative, forward-thinking organization, and outstanding career and development prospects. We offer an exciting company culture that stands for integrity, intensity, involvement, and innovation!

ThermoFisher is committed to crafting a diverse work environment that values and respects individuals from all backgrounds. Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.