Manager, Antibody Characterization

Twist Bioscience is seeking a highly motivated and enthusiastic Manager, Antibody Characterization to join our dynamic Operations Team. This is an exciting opportunity to lead a critical function within a fast-paced, high-growth synthetic biology environment. The ideal candidate will thrive on the challenge of building new product lines while enforcing the rigor and accountability essential for delivering world-class, high-quality products to both internal and external customers.

Onsite - 5 Days per week - Wilsonville, Oregon.

What You’ll Be Doing:

Manage, train, and mentor production team members, fostering a collaborative and high-performing laboratory environment.
Overseeing, running, and troubleshooting antibody characterization experiments using advanced analytical techniques (e.g. BLI and SPR) in a variety of formats to evaluate binding kinetics, ligand blocking, and binning.
Act as the primary point of contact for shift Manufacturing Associates and Specialists, ensuring the team adheres to the plan of record.
Provide guidance, oversee priority decisions, and lead troubleshooting efforts for production issues as they arise.
Establish and track Key Performance Indicators (KPIs) to drive production efficiency and meet department goals.
Model capacity and recommend high-throughput workflow options and staffing plans based on demand forecasts.
Drive operational excellence by identifying and implementing Continuous Process Improvement (CPI) initiatives to increase capacity, reduce Turnaround Time (TAT), and lower Cost of Goods Sold (COGS).
Lead complex technical investigations and risk assessments related to processes, including resolving customer incidents.
Maintain thorough, accurate, and detailed documentation of all work in batch records, databases, or other approved formats, including problems and deviations.
Develop and revise Standard Operating Procedures (SOPs), work instructions, and training documents for the characterization of proteins/antibodies.
Ensure the team operates in compliance with necessary quality standards.
Collaborate with internal and external customers on protein production projects
Work closely with the Director and support functions to evaluate opportunities for product line improvements, contributing to Twist's strategic vision.
Lead cross-functional projects, including running recurring status meetings and managing assignments across teams in the US, Europe, and Asia.

What You'll Bring to the Team

B.S. or M.S. degree in Biology, Biochemistry, Immunology, Process Engineering, or a related field.
5+ years of experience in the biotech/pharmaceutical industry, preferably involving the characterization of diagnostic and/or therapeutic antibodies.
Strong understanding of antibody discovery, preferably focusing on assay development and protein characterization
Previous experience with BLI, SPR, and ELISA strongly preferred.
A proven track record of successfully developing and manufacturing protein-based commercial products.
Demonstrated scientific leadership, mentoring, and organizational skills in managing direct reports and overseeing external collaborations (e.g., CROs).
Deep expertise in basic synthetic/molecular biology skills, including Mammalian Cell Culturing, Transfection, Buffer Exchange, and molecular biology workflows.
Excellent project management skills: proficient with timeline development, project tracking, and the ability to efficiently manage and prioritize multiple projects.
Exceptional attention to detail, organizational, and record-keeping skills.
Familiarity with PLM, ERP, and MES management systems is a plus.

#LI-LK1

Details

Location

Wilsonville, OR, USA Portland, OR, USA Oregon, USA United States

Experience

Min. 5 yearsyears of experience in biotech/pharmaceutical industry

Onsite - 5 Days per week - Wilsonville, Oregon.

What You’ll Be Doing:

Manage, train, and mentor production team members, fostering a collaborative and high-performing laboratory environment.
Overseeing, running, and troubleshooting antibody characterization experiments using advanced analytical techniques (e.g. BLI and SPR) in a variety of formats to evaluate binding kinetics, ligand blocking, and binning.
Act as the primary point of contact for shift Manufacturing Associates and Specialists, ensuring the team adheres to the plan of record.
Provide guidance, oversee priority decisions, and lead troubleshooting efforts for production issues as they arise.
Establish and track Key Performance Indicators (KPIs) to drive production efficiency and meet department goals.
Model capacity and recommend high-throughput workflow options and staffing plans based on demand forecasts.
Drive operational excellence by identifying and implementing Continuous Process Improvement (CPI) initiatives to increase capacity, reduce Turnaround Time (TAT), and lower Cost of Goods Sold (COGS).
Lead complex technical investigations and risk assessments related to processes, including resolving customer incidents.
Maintain thorough, accurate, and detailed documentation of all work in batch records, databases, or other approved formats, including problems and deviations.
Develop and revise Standard Operating Procedures (SOPs), work instructions, and training documents for the characterization of proteins/antibodies.
Ensure the team operates in compliance with necessary quality standards.
Collaborate with internal and external customers on protein production projects
Work closely with the Director and support functions to evaluate opportunities for product line improvements, contributing to Twist's strategic vision.
Lead cross-functional projects, including running recurring status meetings and managing assignments across teams in the US, Europe, and Asia.

What You'll Bring to the Team

B.S. or M.S. degree in Biology, Biochemistry, Immunology, Process Engineering, or a related field.
5+ years of experience in the biotech/pharmaceutical industry, preferably involving the characterization of diagnostic and/or therapeutic antibodies.
Strong understanding of antibody discovery, preferably focusing on assay development and protein characterization
Previous experience with BLI, SPR, and ELISA strongly preferred.
A proven track record of successfully developing and manufacturing protein-based commercial products.
Demonstrated scientific leadership, mentoring, and organizational skills in managing direct reports and overseeing external collaborations (e.g., CROs).
Deep expertise in basic synthetic/molecular biology skills, including Mammalian Cell Culturing, Transfection, Buffer Exchange, and molecular biology workflows.
Excellent project management skills: proficient with timeline development, project tracking, and the ability to efficiently manage and prioritize multiple projects.
Exceptional attention to detail, organizational, and record-keeping skills.
Familiarity with PLM, ERP, and MES management systems is a plus.

#LI-LK1